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Selected publications
[ Featured Lab Articles
| Featured Collaborative Articles
| Featured Reviews or Previews
| Main Research Articles
| Reviews, Book Chapters and Highlights
| Pre-prints
| Collaborative Publication]
Featured Lab Articles
See more details
Featured Collaborative Articles
Featured Reviews or Previews
Main Research Articles
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· Yang J., Zhao, T., Fan, J., Zou, H., Lan, G., Guo, F., Shi, Y., Ke, H., Yu, H., Yue, Z., Wang, X., Bai Y., Li, S., Liu, Y., Wang, X., Chen, Y., Li, Y.*, & Lei, X.* (2024) Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
Cell. DOI:10.1016/j.cell.2024.10.001.
[Full Text]
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[Supplemental Data]
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· Lv, M., Cai, R., Zhang, R., Xia, X.,
Li, X., Wang, Y., Wang, H., Zeng, J., Xue, Y., Mao, L., & Li, Y.* (2024).
An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.
National Science Review. 11(5): nwae112.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2024.03.09.584200
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· Umpierre, A. D.#*, Li, B.#, Ayasoufi, K., Simon, W. L.,
Zhao, S., Xie, M., Thyen, G., Hur, B., Zheng, J., Liang, Y., Bosco, D. B., Maynes, M. A., Wu, Z.,
Yu, X., Sung, J., Johnson, A. J., Li, Y.*, & Wu, L.-J.* (2024)
Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune
responses in epileptogenesis.
Neuron. 112(12): 1959-1977. e10.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.06.12.544691v1
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· Feng, J.*, Dong, H., Lischinsky, J. E., Zhou, J., Deng, F.,
Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., Xie, H., Cui, G., Lin, D.,
& Li, Y.* (2024).
Monitoring norepinephrine release in vivo using next-generation GRABNE sensors.
Neuron.. 112(12): 1930-1942. e6.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2023.06.22.546075
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· Deng, F.#, Wan, J.#, Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y., Liu, L., Yan, Y., Feng, J., Zhao, Y., Xie, H., & Li, Y.*(2024).
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo.
Nature Methods. 21(4): 692-702.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2023.05.27.542566
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· Zhuo, Y.#, Luo, B.#, Yi, X., Dong, H.,
Miao, X., Wan, J., Williams, J. T., Campbell, M. G., Cai, R., Qian, T.,
Li, F., Weber, S. J., Wang, L., Li, B., Wei, Y., Li, G., Wang, H.,
Zheng, Y., Zhao, Y., Wolf, M. E., Zhu, Y., Watabe-Uchida, M., &
Li, Y.* (2024). 21(4): 680-691.
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.
Nature Methods.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2023.08.24.554559v1
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Wang, H.#, Qian, T.#, Zhao, Y., Zhuo, Y., Wu, C., Osakada, T.,
Chen, P., Chen, Z., Ren, H., Yan, Y., Geng, L., Fu, S.,
Mei, L., Li, G., Wu, L., Jiang, Y., Qian, W., Zhang, L., Peng, W., Xu, M., Hu, J.,
Jiang, M., Chen, L., Tang, C., Zhu, Y., Lin, D., Zhou, J.-N., & Li, Y.* (2023).
A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors.
Science , 382(6672), eabq8173.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.03.26.485911
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· Wu, Z.#, Cui, Y.#, Wang, H.#, Wu, H., Wan, Y.,
Li, B., Wang, L., Pan, S., Peng, W., Dong, A., Yuan, Z., Jing, M.,
Xu, M., Luo, M.*, & Li, Y.* (2023).
Neuronal activity-induced, equilibrative nucleoside transporter-dependent,
somatodendritic adenosine release revealed by a GRAB sensor.
Proceedings of the National Academy of Sciences, 120(14), e2212387120.
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[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.05.04.075564
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· Dong, H.#, Li, M.#, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R., & Li, Y.* (2023).
Genetically encoded sensors for measuring histamine release both in vitro and in vivo.
Neuron. 111(10): 1564-1576. e6.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.08.19.504485
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· Zeng, J.#*, Li, X.#, Zhang, R., Lv, M., Wang, Y., Tan, K., Xia, X., Wan, J., Jing, M., Zhang, X., Li, Y., Yang, Y., Wang, L., Chu, J., Li, Y., & Li, Y.*. (2023).
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.
Neuron. 111(7): 1118-1135. e5.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.03.27.485970
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· Qian, T.#, Wang, H.#, Wang, P.#, Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., & Li, Y.* (2023).
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.
Nature Biotechnology. 41(7): 944-957.
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2022.02.10.480016
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· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T.,
Wang, H., Du, J., Jing, M., & Li, Y.* (2021). A sensitive GRAB sensor for detecting extracellular
ATP in vitro and in vivo Neuron, 110(5), 770-782.e775.
[Full Text]
[PDF]
[Supplemental Data]
* See Comments Highlight by: Umpierre, A. D., Haruwaka, K., & Wu, L.-J.* (2022).
Getting a sense of ATP in real time.
Neuroscience Bulletin.
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See also BioRxiv https://doi.org/10.1101/2021.02.24.432680
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· Dong, A., He, K., Dudok, B., Farrell, J. S.,
Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Wang, H., Duan, J., Albarran, E.,
Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y.*. (2021).
A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo.
Nature Biotechnology. 40(5): 787-798.
[Full Text]
[PDF]
[Supplemental Data]
See also BioRxiv https://www.biorxiv.org/content/10.1101/2020.10.08.329169
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· Qian, C., Wu, Z., Sun, R., Yu, H., Zeng, J., Rao, Y., & Li, Y. *.
(2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife. 10: e65417.
https://doi.org/10.7554/eLife.65417.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2020.12.01.405605
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· Wan, J., Peng, W., Li, X., Qian, T.,
Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J.,
Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.
(2021). A genetically encoded sensor for measuring serotonin dynamics.
Nature Neuroscience. 24(5): 746-752. https://doi.org/10.1038/s41593-021-00823-7.
[Full Text]
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[Supplemental Data]
See also BioRxiv https://doi.org/10.1101/2020.02.24.962282
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· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020).
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods. 17(11), 1156-1166.
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· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J. , Trinh, S., Wu, R., Zhang, S., Pan, S., Hires, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020).
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, 17(11), 1139-1146.
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· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*.
(2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.
[Full Text]
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· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.
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· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors.
Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.
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· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366.
[Full Text]
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[Supplemental Data]
* See Insight by: Kick, D. R., & Schulz, D. J. (2019). Cell Communication: Studying gap junctions with PARIS. eLife, 8, e45207.
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· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J.,
Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z.,
Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G.
& Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and
specific detection of dopamine in flies, fish, and mice. Cell,
174(2), 481-496.
[Full Text]
[PDF]
[Supplemental Data]
[Supplemental Video 1]
[Supplemental Video 2]
* See Viewpoint
by: Beyene, A. G., Delevich, K., Yang, S. J., & Landry, M. P. (2018). New optical probes bring dopamine to light.
Biochemistry, 6379-6381. [Full Text][PDF> |
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· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*.
(2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737.
[Full Text]
[PDF][Supplemental Data]
[Supplemental Videos]
* See Research Highlight by: Vogt, N. (2018). Detecting acetylcholine. Nature methods, 15(9), 648.
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· Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053.
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[Supplemental Data]
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· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187.
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Reviews, Book Chapters and Highlights
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· Deng, F., Feng, J., Xie,H., & Li, Y.* (2025).
Mesoscopic Imaging of Neurotransmitters and Neuromodulators with Genetically Encoded Sensors.
Awake Behaving Mesoscopic Brain Imaging. Neuromethods, vol 214. Humana, New York.
[Full Text]
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· Wan, J., & Li, Y.* (2024).
STX-bpc: “Brightening” the path to neuronal inhibition.
Cell Chemical Biology. 31(7): 1233-1235.
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· Yang, Y.#, Li, B.#, & Li, Y.* (2024).
Genetically Encoded Sensors for the In Vivo Detection of Neurochemical Dynamics.
Annual Review of Analytical Chemistry. 17.
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· Zhao, Y., Wan, J., & Li, Y.* (2024).
Genetically encoded sensors for in vivo detection of neurochemicals relevant to depression.
Journal of Neurochemistry. 17.
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· Zheng, Y., & Li, Y.* (2023).
Past, Present, and Future of Tools for Dopamine Detection.
Neuroscience, 525, 13-25.
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· Qian, T., Wang, H., Xia, X., & Li, Y.* (2023)
Current and emerging methods for probing neuropeptide transmission.
Current Opinion in Neurobiology, 81, 102751.
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· Dong, C.#, Zheng, Y.#, Long-Iyer, K., Wright, E. C., Li, Y.*, & Tian, L.* (2022).
Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors.
Annual Review of Neuroscience. 45(1): 273-294.
[Full Text]
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· Wu, Z., Lin, D., & Li, Y.* (2022).
Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.
Nature Reviews Neuroscience. 23(5): 257-274.
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· Zhuo, Y., Li, Y.* (2022). New imaging methods for monitoring dopaminergic neurotransmission. Science China Life Sciences, 65.
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· Yulong Li. (2021). Neuron, 109(21), 3346-3348.
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· Yu, H., Wangensteen, K., Deng, T., Li, Y., & Luo, W.* (2021). MRGPRX4 in Cholestatic Pruritus. Semin Liver Dis41(03), 358-367.
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· Wan, J. & Li, Y.* (2020). Recent advances in detection methods for neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese)
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· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008.
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· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010.
[Full Text]
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· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855. [Full Text] [PDF]
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· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap junctions in the nervous system: probing functional connections using new imaging approaches. Frontiers in Cellular Neuroscience, 12, 320.
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· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178.
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· Wang, A.#, Feng, J.#, Li, Y.*, & Zou, P.* (2018). Beyond fluorescent proteins: hybrid and bioluminescent indicators for imaging neural activities. ACS chemical neuroscience, 9(4), 639-650.
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· Qian, C., & Li, Y.* (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929.
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· Li, Y.*, & Rao, Y.* (2015). Pied piper of neuroscience. Cell, 163(2), 267-268.
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Pre-prints
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· Lopez, R., Noble, N., Ozcete, O., Cai, X., Handy, G., Andersen, J., Patriarchi, T., Li, Y*, & Kaeser, P.* (2024).
Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors.
bioRxiv.
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· Xia, X., & Li, Y*. (2024).
A new GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release.
bioRxiv, 2024.2005.2022.595424.
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· Liu, Y., Nong, Y., Feng, J., Li, G., Sajda, P., Li, Y., & Wang, Q.* (2024).
Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.
bioRxiv, 2022.2005.2018.492553.
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· Zou, J., Willem, J., Mridha, Z., Trinh, S., Erskine, A., Jing, M., Yao, J., Walker, S., Li, Y., McGinley, M., Hires, S.* (2024)
Goal-directed motor actions drive acetylcholine dynamics in sensory cortex
eLife , 13:RP96931
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· Costa, K. M.#*, Zhang, Z.#*, Zhuo, Y., Li, G., Li, Y., & Schoenbaum, G.* (2024).
Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states.
bioRxiv, 2024.2005.2003.592439.
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· Kalogriopoulos, N. A.#, Tei, R.#, Yan, Y., Ravalin, M., Li, Y., & Ting, A.* (2024).
Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior.
bioRxiv, 2024.2004.2015.589622.
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· Fan, J., Wang, Y., Li, L., He, J., Zhao, Z., Deng, F., Li, G, Li X., Zhou, Y., Zhao, J., Li, Y., Wu, J., Fang, L., & Dai, Q* (2024).
Prominent involvement of acetylcholine in shaping stable olfactory representation across the Drosophila brain.
bioRxiv, 2024.04.03.587915.
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· Wang T., Zhang X., Duan H., Xia D., Li T., Yan R., Zhan Y., Li, Y., Gao W., & Zhou, Q.* (2024).
Gating of Memory to Behavior by the Locus Coeruleus.
bioRxiv, 2024.01.09.574947.
[Full Text]
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· Straub, V., Barti, B., Tandar, S., Stevens, A., van der Wel, T., Zhu, N., Rüegger, J., van der Horst, C., Heitman, L., Li, Y., Stella, N., van Hasselt, J. G., Coen Katona, I., van der Stelt, M.* (2024).
The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles.
bioRxiv, 2024.09.23.614520.
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· Ai M., Takeshi K., Naoki N., Yuka T., Yoan C., Yukiko I., Li, Y., Hotaka T., Jun S., Masashi Y., Takeshi S., Katsuyasu S., & Liu, Q.* (2024).
Sequential Transitions of Male Sexual Behaviors Driven by Dual Acetylcholine-Dopamine Dynamics.
bioRxiv, 2023.12.21.572798.
[Full Text]
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· Sun, D., Ng, S., Zheng, Y., Xie, S. , Schwan, N., Breuer P., Hoffmann, D., Michel, J., Azorin, D., Boonekamp, K., Winkler, F., Wick, W., Boutros, M., Li, Y., & Johnsson, K.* (2024).
Molecular recording of cellular protein kinase activity with chemical labeling.
bioRxiv, 2024.09.11.611894.
[Full Text]
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· Ge, C., Chen, Z., Sun, F., Hou, R., Fan, H., Li, Y., & Li, C.* (2024).
Timing-dependent modulation of working memory by VTA dopamine release in medial prefrontal cortex.
bioRxiv, 2024.09.11.611894.
[Full Text]
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· Wu, Y., Gu, X., Kong, Y., Yang, S., Wang, H., Xu, M., Wang, Q., Yi, X., Lin, Z., Jiao, Z., Cheung, H., Zhao, X., Bian, X., Jiang, Q., Li, Y., Zhu, M., Wang, L., Li, Y., Huang, J., Li, Q., Li, W., & Xu, T.* (2024).
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability.
bioRxiv, 2024.05.09.593455.
[Full Text]
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· Wang, H., Ortega, H., Kelly, E., Indajang, E., Feng, J. , Li, Y., & Kwan, A.* (2024).
Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.
bioRxiv, 2024.01.23.576893.
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· Garcia, S., Laffere, A., Toschi, C., Schilling, L., Podlaski, J., Fritsche, M., Zatka-Haas, P., Li, Y., Bogacz, R., Saxe, A., & Lak, A.* (2023).
Striatal dopamine reflects individual long-term learning trajectories.
bioRxiv, 2023.12.14.571653.
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· Guo, Q., Hou, T., Xie, W., Zhang, J., Ma, X., Guo, Y., Wang, X., Wang, L., Lu, M., Wu, Z, Wang, H., Chen, Y., Li, Y., & Wang, S.*(2024).
Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria.
bioRxiv, 2024.09.30.615983.
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· Yang, J., Basu, A., Liu, R., Staszko, S., Yu, A., Rondeau, J., Glaeser-Khan, S., Feng, J., Li, Y., Che, A., & Kaye, A.* (2023).
Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model.
bioRxiv, 2023.11.27.568929.
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· Touhara, K., Rossen, N., Deng, F., Chu, T., Harrington, A., Caraballo, S., Brizuela, M., O'Donnell, T., Cil, O., Brierley, S., Li, Y., & Julius, D.* (2024).
Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut.
bioRxiv, 2024.02.06.579180.
[Full Text]
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· Singh, S., Sarroza, D., English, A., Whittington, D., Dong, A., van der Stelt, M., Li, Y., Zweifel, L., Bruchas, M. R., Land, B. B., & Stella, N.* (2022).
ABHD6 selectively controls metabotropic-dependent increases in 2-AG production.
bioRxiv, 2024.2005.2017.594562.
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· Jiang, P.*, Kemper, K. M., Chang, K.-T., Qian, C., Li, Y., Guan, L., van Hasselt, P., Caradonna, S. J., & Strich, R. (2022).
An in situ cut-and-paste genome editing platform mediated by CRISPR/Cas9 or Cas12a.
bioRxiv, 2022.2003.2030.486486.
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· Zou, J., Trinh, S., Erskine, A., Jing, M., Yao, J., Walker, S., Li, Y.., & Hires, S. A.* (2021). Directed motor actions and choice signalling drive cortical acetylcholine dynamics. bioRxiv,, 2021.2012.2021.473699.
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· Sturgill, J. F., Hegedus, P., Li, S. J., Chevy, Q, Siebels, A., Jing, M., Li, Y., Hangya, B.* & Kepecs, A.*(2020). Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error. bioRxiv, 2020.02.17.953141.
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Collaborative Publication
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· Li, H., Zhao, Y., Dai, R. , Geng, P., Weng, D., Wu, W., Yu, F., Lin, R., Wu, Z. , Li, Y., & Luo, M.* (2024)
Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis.
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